Anti-AgingHealth ConditionsSkin & Aging
Anti-Aging Herbs: Natural Solutions for Longevity and Vitality
Introduction: The Quest for Natural Anti-Aging Solutions
The pursuit of longevity and youthful vitality has been a constant throughout human history. As our understanding of the aging process has evolved, so too has our approach to combating its effects. While modern medicine offers various interventions, there is growing interest in natural, plant-based solutions that have been used for centuries in traditional medicine systems worldwide [1]. These herbs, rich in bioactive compounds, offer promising benefits for supporting healthy aging through multiple mechanisms—from combating oxidative stress to reducing inflammation and supporting cellular regeneration [2].
This article explores the science behind aging, the most effective anti-aging herbs from various traditional medicine systems, their mechanisms of action, and practical applications for incorporating these natural remedies into daily wellness routines. By understanding how these herbs work and how to use them effectively, individuals can make informed choices about incorporating them into comprehensive anti-aging strategies.
Understanding the Mechanisms of Aging
Aging is a complex, multifaceted process influenced by genetic, environmental, and lifestyle factors. Several key mechanisms contribute to the aging process at cellular and molecular levels:
Oxidative Stress and Free Radical Damage
Free radicals are unstable molecules with unpaired electrons that can damage cellular components, including proteins, lipids, and DNA [3]. This oxidative damage accumulates over time, contributing to aging and age-related diseases. The body produces antioxidant enzymes to neutralize free radicals, but this defense system becomes less efficient with age [4]. Environmental factors like pollution, UV radiation, and poor diet can accelerate oxidative damage.
Telomere Shortening
Telomeres are protective caps at the ends of chromosomes that shorten with each cell division. When telomeres become critically short, cells enter a state of senescence (they stop dividing) or undergo apoptosis (programmed cell death) [5]. This process limits the lifespan of cells and contributes to tissue aging. The enzyme telomerase can maintain telomere length, but its activity decreases in most cells as we age [6].
Chronic Inflammation
Low-grade, chronic inflammation, sometimes called “inflammaging,” is a significant contributor to the aging process [7]. This persistent inflammatory state can damage tissues and accelerate aging. Inflammatory processes are regulated by complex signaling pathways, including nuclear factor-kappa B (NF-κB) and various cytokines [8].
Mitochondrial Dysfunction
Mitochondria are the cellular powerhouses responsible for energy production. With age, mitochondrial function declines, leading to decreased energy production and increased generation of reactive oxygen species (ROS) [9]. This dysfunction creates a vicious cycle of oxidative damage and further mitochondrial impairment, contributing significantly to the aging process [10].
Advanced Glycation End Products (AGEs)
AGEs form when sugars react with proteins or lipids without enzymatic control (glycation). These modified molecules can cross-link, causing stiffening of tissues and contributing to aging, particularly in the skin and blood vessels [11]. AGEs accumulate naturally with age but can be accelerated by high blood sugar levels and certain cooking methods [12].
Cellular Senescence
Senescent cells no longer divide but remain metabolically active, secreting pro-inflammatory cytokines, chemokines, and matrix metalloproteinases collectively known as the senescence-associated secretory phenotype (SASP) [13]. The accumulation of senescent cells contributes to tissue dysfunction and aging [14].
Understanding these mechanisms provides the foundation for appreciating how anti-aging herbs exert their beneficial effects, as many target multiple pathways simultaneously.
Ayurvedic Herbs with Anti-Aging Properties
Ayurveda, the traditional medicine system of India dating back over 5,000 years, offers a rich pharmacopeia of herbs with anti-aging (rasayana) properties. These herbs have been extensively studied for their bioactive compounds and mechanisms of action:
Butea monosperma (Flame of the Forest)
This majestic tree, known for its vibrant orange-red flowers, contains numerous bioactive compounds including gallic acid, ellagic acid, and rosmarinic acid [15]. These compounds exhibit potent antioxidant properties, neutralizing free radicals and reducing oxidative stress [16]. Research has shown that Butea monosperma extracts can inhibit lipid peroxidation and enhance the activity of antioxidant enzymes like superoxide dismutase and catalase [17].
Phyllanthus niruri (Stone Breaker)
This small herb is rich in lignans, flavonoids, and tannins that contribute to its remarkable antioxidant and anti-inflammatory properties [18]. Studies have demonstrated that Phyllanthus niruri can protect against DNA damage, inhibit lipid peroxidation, and modulate inflammatory pathways [19]. Its hepatoprotective effects may also contribute to its anti-aging benefits by supporting detoxification processes [20].
Holarrhena antidysenterica (Kurchi)
The bark and seeds of this plant contain alkaloids like conessine, holarrifine, and kurcholessine, which exhibit antioxidant, anti-inflammatory, and immunomodulatory properties [21]. Research suggests that these compounds can reduce oxidative stress and inflammation, potentially slowing the aging process [22]. Traditional Ayurvedic texts recommend Holarrhena for promoting longevity and vitality [23].
Picrorhiza kurroa (Kutki)
This high-altitude herb contains iridoid glycosides, cucurbitacins, and phenolic compounds like vanillic acid, apocynin, and gallic acid [24]. These compounds have demonstrated significant antioxidant, anti-inflammatory, and immunomodulatory effects in various studies [25]. Picrorhiza has been shown to protect against oxidative damage in liver cells and may help maintain cellular health during aging [26].
Psoralea corylifolia (Babchi)
The seeds of this plant contain unique compounds including psoralen, bakuchiol, and bakuchicin, which have shown remarkable skin-rejuvenating properties [27]. Bakuchiol, in particular, has gained attention as a natural alternative to retinol, promoting collagen production and reducing the appearance of fine lines and wrinkles without the irritation often associated with retinoids [28]. Studies have shown that Psoralea extracts can protect against UV damage and improve skin elasticity [29].
Rauwolfia serpentina (Indian Snakeroot)
This plant contains alkaloids like ajmaline, ajmalimine, and serpentine, which have traditionally been used for their anti-aging and adaptogenic properties [30]. Research has shown that these compounds can reduce oxidative stress, support cardiovascular health, and potentially protect against neurodegenerative processes [31]. However, due to its potent effects on blood pressure, Rauwolfia should only be used under professional guidance [32].
Swertia cordata (Chirayata)
Rich in xanthones, iridoids, and triterpenes like ursolic acid and mangiferin, Swertia has demonstrated neuroprotective, antioxidant, and anti-inflammatory properties [33]. Studies suggest that these compounds can protect neurons from oxidative damage and may help maintain cognitive function during aging [34]. Traditional use of Swertia focuses on its bitter tonic properties that support digestion and metabolism [35].
Global Anti-Aging Herbs Beyond Ayurveda
While Ayurveda offers a rich tradition of anti-aging herbs, other medical systems worldwide have identified powerful plant allies for healthy aging:
Panax ginseng (Asian Ginseng)
Revered in Traditional Chinese Medicine for millennia, ginseng contains ginsenosides that have demonstrated remarkable anti-aging properties [36]. Research shows that these compounds can enhance cognitive function, improve energy metabolism, reduce oxidative stress, and modulate inflammatory responses [37]. Ginseng may also support the body’s stress response through effects on the hypothalamic-pituitary-adrenal (HPA) axis [38].
Ginkgo biloba (Maidenhair Tree)
One of the oldest living tree species, Ginkgo contains flavonoids and terpenoids that improve microcirculation and protect against oxidative damage [39]. Clinical studies have shown that standardized Ginkgo extracts can support cognitive function in older adults and may help maintain memory and attention [40]. Its ability to improve peripheral circulation may also benefit skin health and vitality [41].
Rhodiola rosea (Golden Root)
This adaptogenic herb from cold, mountainous regions contains unique compounds like salidroside and rosavin that help the body adapt to physical, chemical, and environmental stress [42]. Research indicates that Rhodiola can reduce fatigue, enhance mental performance, and protect against stress-induced cellular damage [43]. Its effects on cellular energy metabolism may contribute to its anti-aging benefits [44].
Astragalus membranaceus (Huang Qi)
A fundamental herb in Traditional Chinese Medicine, Astragalus contains polysaccharides and astragalosides that have demonstrated immune-enhancing and anti-aging effects [45]. Particularly noteworthy is its potential effect on telomerase activity, possibly helping to maintain telomere length and cellular longevity [46]. Astragalus has also shown cardiovascular benefits that may contribute to healthy aging [47].
Schisandra chinensis (Five-Flavor Berry)
Named for its complex flavor profile, Schisandra contains lignans that support liver function, enhance stress resistance, and exhibit potent antioxidant properties [48]. Research suggests that Schisandra can improve physical performance, reduce fatigue, and protect against various types of stress-induced damage [49]. Its adaptogenic properties may help maintain physiological balance during aging [50].
Bacopa monnieri (Brahmi)
Traditionally used in Ayurveda for cognitive enhancement, Bacopa contains bacosides that have demonstrated neuroprotective and cognitive-enhancing properties [51]. Clinical studies show that Bacopa supplementation can improve memory, attention, and information processing [52]. Its antioxidant properties may protect neural tissues from age-related oxidative damage [53].
Curcuma longa (Turmeric)
The active compound in turmeric, curcumin, has powerful anti-inflammatory and antioxidant properties [54]. Research has shown that curcumin can modulate multiple signaling pathways involved in inflammation, oxidative stress, and cellular senescence [55]. Its potential to reduce “inflammaging” makes it a valuable herb for healthy aging [56].
Mechanisms of Action: How Anti-Aging Herbs Work
The herbs discussed above exert their anti-aging effects through multiple, often overlapping mechanisms:
Antioxidant Activity
Many anti-aging herbs contain polyphenols, flavonoids, and other compounds that directly neutralize free radicals [57]. Additionally, some herbs enhance the body’s endogenous antioxidant systems by increasing the production or activity of enzymes like superoxide dismutase, catalase, and glutathione peroxidase [58]. This dual approach provides comprehensive protection against oxidative damage.
Anti-inflammatory Effects
Anti-aging herbs often contain compounds that modulate inflammatory pathways, particularly the NF-κB signaling cascade, which plays a central role in inflammation [59]. By reducing the production of pro-inflammatory cytokines and mediators, these herbs help mitigate the “inflammaging” process [60]. Some herbs also promote the resolution of inflammation through specialized pro-resolving mediators [61].
Enzyme Inhibition
Several herbs contain compounds that inhibit enzymes involved in skin aging, such as elastase, collagenase, and hyaluronidase, which break down structural proteins in the skin [62]. By inhibiting these enzymes, the herbs help maintain skin elasticity and firmness [63]. Similarly, some herbs inhibit tyrosinase, reducing age-related pigmentation [64].
Telomerase Activation
Some herbs, particularly astragalus, have shown potential to activate telomerase, the enzyme responsible for maintaining telomere length [65]. By preserving telomere integrity, these herbs may help delay cellular senescence and extend cellular lifespan [66]. This mechanism is particularly relevant for tissues with high cell turnover rates [67].
Mitochondrial Function Enhancement
Several anti-aging herbs improve mitochondrial function by enhancing energy production efficiency and reducing ROS generation [68]. Some herbs also promote mitochondrial biogenesis, increasing the number of healthy mitochondria in cells [69]. This improvement in cellular energy metabolism supports overall tissue function and resilience [70].
Hormesis and Adaptive Stress Response
Many adaptogenic herbs work through hormesis—a biological phenomenon where low doses of a stressor trigger adaptive responses that improve cellular resilience [71]. These herbs activate stress response pathways like Nrf2, which regulates the expression of antioxidant and detoxification genes [72]. This “pre-conditioning” helps cells better withstand future stressors [73].
Senolytic and Senomorphic Effects
Emerging research suggests that some herbs may have senolytic properties (selectively eliminating senescent cells) or senomorphic effects (modulating the SASP to reduce its harmful effects) [74]. By reducing the burden of senescent cells or mitigating their negative impact, these herbs may help maintain tissue function during aging [75].
Practical Applications: How to Use Anti-Aging Herbs
Incorporating anti-aging herbs into daily routines can be done through various methods, each with specific considerations:
Internal Use: Supplements and Formulations
Standardized Extracts
Standardized herbal extracts ensure consistent levels of active compounds and are typically available as capsules, tablets, or liquid extracts [76]. When selecting supplements, look for products standardized to specific bioactive compounds (e.g., ginsenosides in ginseng or bacosides in Bacopa) [77]. Typical dosages vary by herb:
•Ashwagandha: 300-600 mg daily of root extract standardized to 5% withanolides [78]
•Ginseng: 200-400 mg daily of extract standardized to 4-7% ginsenosides [79]
•Ginkgo biloba: 120-240 mg daily of extract standardized to 24% flavone glycosides and 6% terpene lactones [80]
•Rhodiola: 200-600 mg daily of extract standardized to 3% rosavins and 1% salidroside [81]
•Turmeric: 500-1000 mg daily of extract standardized to 95% curcuminoids, preferably with enhanced bioavailability [82]
Herbal Teas and Decoctions
Teas offer a gentle way to incorporate anti-aging herbs into daily routines:
•Ginger and Turmeric Tea: Combine 1 teaspoon each of fresh grated ginger and turmeric with hot water, steep for 10 minutes, and add honey and lemon to taste. This provides anti-inflammatory and antioxidant benefits [83].
•Adaptogenic Blend: Mix equal parts of dried holy basil, ashwagandha, and Schisandra berries. Use 1 tablespoon per cup of hot water and steep for 15 minutes. This supports stress resilience and overall vitality [84].
•Cognitive Support Tea: Combine 1 part Bacopa, 1 part Ginkgo, and 1 part Gotu Kola. Use 1 teaspoon per cup and steep for 10 minutes. This blend supports brain health and cognitive function [85].
Herbal Powders and Formulations
Traditional formulations often combine multiple herbs for synergistic effects:
•Triphala: This classic Ayurvedic formula combines three fruits (amalaki, bibhitaki, and haritaki) and supports digestion, elimination, and cellular rejuvenation. Typical dose is 1/2 to 1 teaspoon before bed with warm water [86].
•Chyawanprash: This traditional Ayurvedic jam contains over 40 herbs and is rich in antioxidants. It’s typically consumed in 1-2 teaspoon doses in the morning [87].
•Adaptogenic Blends: Formulations combining herbs like ashwagandha, Rhodiola, and Schisandra can be added to smoothies or warm milk (1/2 to 1 teaspoon daily) [88].
External Use: Topical Applications
Herbal Oils and Serums
Herbs can be infused into carrier oils for topical anti-aging benefits:
•Turmeric and Sandalwood Oil: Infuse 1 tablespoon each of turmeric and sandalwood powder in 1 cup of sesame oil for 2 weeks. Strain and apply to the skin at night for brightening and rejuvenating effects [89].
•Gotu Kola Serum: Combine Gotu Kola extract with hyaluronic acid and jojoba oil for a serum that supports collagen production and skin elasticity [90].
•Bakuchiol Facial Oil: Mix bakuchiol extract (from Psoralea corylifolia) with rosehip and argan oils for a natural retinol alternative that reduces fine lines without irritation [91].
Herbal Masks and Treatments
•Triphala Brightening Mask: Mix 1 teaspoon Triphala powder with honey and yogurt to form a paste. Apply to clean skin for 15-20 minutes before rinsing. This gently exfoliates and brightens the complexion [92].
•Ginseng Revitalizing Mask: Combine ginseng extract or powder with aloe vera gel and a drop of essential oil. Apply to the face for 20 minutes to improve circulation and skin tone [93].
•Herbal Steam: Add dried herbs like lavender, rose, and calendula to hot water and steam the face under a towel for 5-10 minutes to open pores and infuse skin with herbal benefits [94].
Safety Considerations and Potential Interactions
While herbal remedies are natural, they are not without risks and considerations:
General Precautions
•Standardization and Quality: The potency and quality of herbal products can vary significantly. Choose products from reputable manufacturers that follow Good Manufacturing Practices (GMP) and ideally have third-party testing [95].
•Start Low and Go Slow: Begin with lower doses of herbs and gradually increase as tolerated, monitoring for any adverse effects [96].
•Duration of Use: Some adaptogenic herbs are best used cyclically rather than continuously. Consider taking periodic breaks from supplementation [97].
•Individual Variation: Response to herbs can vary based on genetics, existing health conditions, and other factors. What works for one person may not work for another [98].
Specific Contraindications
•Pregnancy and Breastfeeding: Many herbs have not been adequately studied in pregnant or breastfeeding women and should be avoided unless specifically recommended by a healthcare provider [99].
•Surgery: Many herbs can affect blood clotting and should be discontinued at least 2 weeks before scheduled surgery [100].
•Autoimmune Conditions: Immune-stimulating herbs may potentially exacerbate autoimmune conditions and should be used with caution [101].
•Liver or Kidney Disease: These conditions may affect the metabolism and excretion of herbal compounds, potentially increasing the risk of adverse effects [102].
Potential Interactions
•Blood Thinners: Herbs like ginkgo, ginseng, and turmeric may enhance the effects of anticoagulant and antiplatelet medications, increasing bleeding risk [103].
•Antidepressants: Some herbs, particularly St. John’s Wort, can interact with antidepressants and other psychiatric medications [104].
•Diabetes Medications: Herbs that affect blood sugar levels may interact with diabetes medications, potentially causing hypoglycemia [105].
•Immunosuppressants: Immune-stimulating herbs may counteract the effects of immunosuppressant medications [106].
•Hormone-Sensitive Conditions: Herbs with phytoestrogenic properties may affect hormone-sensitive conditions or interact with hormone therapies [107].
Always consult with a healthcare provider before beginning any herbal regimen, particularly if you have existing health conditions or take medications.
Clinical Applications and Future Prospects
The potential applications of anti-aging herbs extend beyond personal use to various therapeutic and cosmetic contexts:
Integrative Medicine Approaches
Healthcare practitioners increasingly incorporate evidence-based herbal interventions into comprehensive anti-aging protocols [108]. These approaches often combine herbs with lifestyle modifications, nutritional interventions, and conventional treatments when appropriate [109]. Personalized protocols based on individual health assessments can optimize outcomes [110].
Cosmetic and Skincare Applications
The cosmetic industry has embraced botanical ingredients for their anti-aging benefits [111]. Advanced formulation technologies are improving the stability and bioavailability of herbal compounds in topical products [112]. Clinical studies are increasingly validating the efficacy of herb-based skincare for addressing various aspects of skin aging [113].
Nutraceutical Developments
Innovative delivery systems like liposomes, nanoparticles, and phytosomes are enhancing the bioavailability of herbal compounds [114]. Combination products that target multiple aging pathways simultaneously are being developed based on synergistic herb interactions [115]. Personalized supplementation based on genetic and biochemical testing represents an emerging frontier [116].
Research Frontiers
Ongoing research is exploring several promising directions:
•Senolytic Botanicals: Identifying herbs and compounds that selectively eliminate senescent cells or modulate the senescence-associated secretory phenotype [117].
•Epigenetic Modulation: Investigating how herbal compounds influence epigenetic markers associated with aging, potentially “reprogramming” cells toward a more youthful state [118].
•Microbiome Interactions: Understanding how herbs influence the gut microbiome and how these changes may contribute to healthy aging [119].
•Precision Herbal Medicine: Developing approaches that match specific herbs to individual genetic profiles, health status, and aging patterns [120].
Conclusion: A Holistic Approach to Anti-Aging
While anti-aging herbs offer significant benefits, they are most effective when incorporated into a comprehensive approach to healthy aging. This includes:
•Nutrient-Dense Diet: Emphasizing whole foods rich in antioxidants, healthy fats, and anti-inflammatory compounds [121].
•Regular Physical Activity: Combining cardiovascular exercise, strength training, and flexibility work to maintain physical function [122].
•Quality Sleep: Prioritizing sleep hygiene and addressing sleep disorders to support cellular repair and regeneration [123].
•Stress Management: Practicing mindfulness, meditation, or other stress-reduction techniques to mitigate the aging effects of chronic stress [124].
•Social Connection: Maintaining meaningful relationships and social engagement, which are strongly associated with longevity and healthy aging [125].
Anti-aging herbs can complement these lifestyle factors, providing additional support for the body’s natural resilience and regenerative capacity. By understanding the science behind these botanical allies and using them wisely, individuals can harness nature’s wisdom in the pursuit of healthy, vibrant aging.
References
[1] Longo VD, Kennedy BK. Sirtuins in aging and age-related disease. Cell. 2006;126(2):257-268.
[2] Rattan SI. Aging is not a disease: implications for intervention. Aging Dis. 2014;5(3):196-202.
[3] Harman D. Aging: a theory based on free radical and radiation chemistry. J Gerontol. 1956;11(3):298-300.
[4] Finkel T, Holbrook NJ. Oxidants, oxidative stress and the biology of ageing. Nature. 2000;408(6809):239-247.
[5] Blackburn EH, Epel ES, Lin J. Human telomere biology: a contributory and interactive factor in aging, disease risks, and protection. Science. 2015;350(6265):1193-1198.
[6] Shay JW, Wright WE. Telomeres and telomerase: three decades of progress. Nat Rev Genet. 2019;20(5):299-309.
[7] Franceschi C, Campisi J. Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. J Gerontol A Biol Sci Med Sci. 2014;69(Suppl 1):S4-S9.
[8] Chung HY, Kim DH, Lee EK, et al. Redefining chronic inflammation in aging and age-related diseases: proposal of the senoinflammation concept. Aging Dis. 2019;10(2):367-382.
[9] López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G. The hallmarks of aging. Cell. 2013;153(6):1194-1217.
[10] Sun N, Youle RJ, Finkel T. The mitochondrial basis of aging. Mol Cell. 2016;61(5):654-666.
[11] Gkogkolou P, Böhm M. Advanced glycation end products: key players in skin aging? Dermatoendocrinol. 2012;4(3):259-270.
[12] Singh R, Barden A, Mori T, Beilin L. Advanced glycation end-products: a review. Diabetologia. 2001;44(2):129-146.
[13] Coppé JP, Desprez PY, Krtolica A, Campisi J. The senescence-associated secretory phenotype: the dark side of tumor suppression. Annu Rev Pathol. 2010;5:99-118.
[14] Baker DJ, Wijshake T, Tchkonia T, et al. Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders. Nature. 2011;479(7372):232-236.
[15] Raina R, Verma PK, Peshin R, Kour H. Potential of Ayurvedic herbs in skin aging: a review. J Ayurveda Integr Med. 2023;14(1):100604.
[16] Sharma N, Bhardwaj V, Singh S, Ali SA, Gupta DK, Paul S. Butea monosperma bark extract attenuates acute and chronic inflammation in rats: involvement of COX-1 and COX-2 inhibition. J Ethnopharmacol. 2016;194:588-596.
[17] Sehrawat A, Kumar V. Butein imparts free radical scavenging, anti-oxidative and pro-apoptotic properties in the flower extracts of Butea monosperma. Biocell. 2016;40(1):27-35.
[18] Bagalkotkar G, Sagineedu SR, Saad MS, Stanslas J. Phytochemicals from Phyllanthus niruri Linn. and their pharmacological properties: a review. J Pharm Pharmacol. 2006;58(12):1559-1570.
[19] Amin ZA, Abdulla MA, Ali HM, Alshawsh MA, Qadir SW. Assessment of in vitro antioxidant, antibacterial and immune activation potentials of aqueous and ethanol extracts of Phyllanthus niruri. J Sci Food Agric. 2012;92(9):1874-1877.
[20] Harish R, Shivanandappa T. Antioxidant activity and hepatoprotective potential of Phyllanthus niruri. Food Chem. 2006;95(2):180-185.
[21] Siddiqui BS, Ali ST, Testa B, Siddiqui S. Steroidal alkaloids and an androstane derivative from the bark of Holarrhena pubescens. Phytochemistry. 1992;31(5):1805-1807.
[22] Verma G, Dua VK, Agarwal DD, Atul PK. Anti-malarial activity of Holarrhena antidysenterica and Viola canescens, plants traditionally used against malaria in the Garhwal region of north-west Himalaya. Malar J. 2011;10:20.
[23] Sharma PC, Yelne MB, Dennis TJ. Database on medicinal plants used in Ayurveda. Vol. 2. Central Council for Research in Ayurveda & Siddha; 2001.
[24] Kumar R, Gupta YK, Singh S, Arunraja S. Picrorhiza kurroa inhibits experimental arthritis through inhibition of pro-inflammatory cytokines, angiogenesis and MMPs. Phytother Res. 2016;30(1):112-119.
[25] Kant K, Walia M, Agnihotri VK, Pathania V, Singh B. Evaluation of antioxidant activity of Picrorhiza kurroa (leaves) extracts. Indian J Pharm Sci. 2013;75(3):324-329.
[26] Shetty SN, Mengi S, Vaidya R, Vaidya AD. A study of standardized extracts of Picrorhiza kurroa Royle ex Benth in experimental nonalcoholic fatty liver disease. J Ayurveda Integr Med. 2010;1(3):203-210.
[27] Chopra B, Dhingra AK, Dhar KL. Psoralea corylifolia L. (Buguchi) – folklore to modern evidence: review. Fitoterapia. 2013;90:44-56.
[28] Dhaliwal S, Rybak I, Ellis SR, et al. Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing. Br J Dermatol. 2019;180(2):289-296.
[29] Chaudhuri RK, Bojanowski K. Bakuchiol: a retinol-like functional compound revealed by gene expression profiling and clinically proven to have anti-aging effects. Int J Cosmet Sci. 2014;36(3):221-230.
[30] Dey A, De JN. Rauvolfia serpentina (L). Benth. ex Kurz.-A review. Asian J Plant Sci. 2010;9(6):285-298.
[31] Azmi L, Ojha SK, Rao CV. Neuroprotective effect of Rauwolfia serpentina against MPTP-induced neurotoxicity. Metab Brain Dis. 2019;34(1):295-303.
[32] Lobay D. Rauwolfia in the treatment of hypertension. Integr Med (Encinitas). 2015;14(3):40-46.
[33] Brahmachari G, Mondal S, Gangopadhyay A, et al. Swertia (Gentianaceae): chemical and pharmacological aspects. Chem Biodivers. 2004;1(11):1627-1651.
[34] Saha P, Das S. Highlighting the anti-carcinogenic potential of an ayurvedic medicinal plant, Swertia chirata. Asian Pac J Cancer Prev. 2010;11(6):1445-1449.
[35] Joshi P, Dhawan V. Swertia chirayita – an overview. Curr Sci. 2005;89(4):635-640.
[36] Lü JM, Yao Q, Chen C. Ginseng compounds: an update on their molecular mechanisms and medical applications. Curr Vasc Pharmacol. 2009;7(3):293-302.
[37] Kim HJ, Kim P, Shin CY. A comprehensive review of the therapeutic and pharmacological effects of ginseng and ginsenosides in central nervous system. J Ginseng Res. 2013;37(1):8-29.
[38] Lee S, Rhee DK. Effects of ginseng on stress-related depression, anxiety, and the hypothalamic-pituitary-adrenal axis. J Ginseng Res. 2017;41(4):589-594.
[39] Mahadevan S, Park Y. Multifaceted therapeutic benefits of Ginkgo biloba L.: chemistry, efficacy, safety, and uses. J Food Sci. 2008;73(1):R14-R19.
[40] Tan MS, Yu JT, Tan CC, et al. Efficacy and adverse effects of Ginkgo biloba for cognitive impairment and dementia: a systematic review and meta-analysis. J Alzheimers Dis. 2015;43(2):589-603.
[41] Pietri S, Maurelli E, Drieu K, Culcasi M. Cardioprotective and anti-oxidant effects of the terpenoid constituents of Ginkgo biloba extract (EGb 761). J Mol Cell Cardiol. 1997;29(2):733-742.
[42] Panossian A, Wikman G, Sarris J. Rosenroot (Rhodiola rosea): traditional use, chemical composition, pharmacology and clinical efficacy. Phytomedicine. 2010;17(7):481-493.
[43] Hung SK, Perry R, Ernst E. The effectiveness and efficacy of Rhodiola rosea L.: a systematic review of randomized clinical trials. Phytomedicine. 2011;18(4):235-244.
[44] Abidov M, Crendal F, Grachev S, Seifulla R, Ziegenfuss T. Effect of extracts from Rhodiola rosea and Rhodiola crenulata (Crassulaceae) roots on ATP content in mitochondria of skeletal muscles. Bull Exp Biol Med. 2003;136(6):585-587.
[45] Liu P, Zhao H, Luo Y. Anti-aging implications of Astragalus membranaceus (Huangqi): a well-known Chinese tonic. Aging Dis. 2017;8(6):868-886.
[46] Molgora B, Bateman R, Sweeney G, et al. Functional assessment of pharmacological telomerase activators in human T cells. Cells. 2013;2(1):57-66.
[47] Fu J, Wang Z, Huang L, et al. Review of the botanical characteristics, phytochemistry, and pharmacology of Astragalus membranaceus (Huangqi). Phytother Res. 2014;28(9):1275-1283.
[48] Panossian A, Wikman G. Pharmacology of Schisandra chinensis Bail.: an overview of Russian research and uses in medicine. J Ethnopharmacol. 2008;118(2):183-212.
[49] Chun JN, Cho M, So I, Jeon JH. The protective effects of Schisandra chinensis fruit extract and its lignans against cardiovascular disease: a review of the molecular mechanisms. Fitoterapia. 2014;97:224-233.
[50] Szopa A, Ekiert R, Ekiert H. Current knowledge of Schisandra chinensis (Turcz.) Baill. (Chinese magnolia vine) as a medicinal plant species: a review on the bioactive components, pharmacological properties, analytical and biotechnological studies. Phytochem Rev. 2017;16(2):195-218.
[51] Aguiar S, Borowski T. Neuropharmacological review of the nootropic herb Bacopa monnieri. Rejuvenation Res. 2013;16(4):313-326.
[52] Pase MP, Kean J, Sarris J, Neale C, Scholey AB, Stough C. The cognitive-enhancing effects of Bacopa monnieri: a systematic review of randomized, controlled human clinical trials. J Altern Complement Med. 2012;18(7):647-652.
[53] Bhattacharya SK, Bhattacharya A, Kumar A, Ghosal S. Antioxidant activity of Bacopa monniera in rat frontal cortex, striatum and hippocampus. Phytother Res. 2000;14(3):174-179.
[54] Hewlings SJ, Kalman DS. Curcumin: a review of its effects on human health. Foods. 2017;6(10):92.
[55] Gupta SC, Patchva S, Aggarwal BB. Therapeutic roles of curcumin: lessons learned from clinical trials. AAPS J. 2013;15(1):195-218.
[56] Bielak-Zmijewska A, Grabowska W, Ciolko A, et al. The role of curcumin in the modulation of ageing. Int J Mol Sci. 2019;20(5):1239.
[57] Pandey KB, Rizvi SI. Plant polyphenols as dietary antioxidants in human health and disease. Oxid Med Cell Longev. 2009;2(5):270-278.
[58] Forman HJ, Davies KJ, Ursini F. How do nutritional antioxidants really work: nucleophilic tone and para-hormesis versus free radical scavenging in vivo. Free Radic Biol Med. 2014;66:24-35.
[59] Gupta SC, Sundaram C, Reuter S, Aggarwal BB. Inhibiting NF-κB activation by small molecules as a therapeutic strategy. Biochim Biophys Acta. 2010;1799(10-12):775-787.
[60] Serhan CN, Chiang N, Van Dyke TE. Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators. Nat Rev Immunol. 2008;8(5):349-361.
[61] Serhan CN, Levy BD. Resolvins in inflammation: emergence of the pro-resolving superfamily of mediators. J Clin Invest. 2018;128(7):2657-2669.
[62] Thring TS, Hili P, Naughton DP. Anti-collagenase, anti-elastase and anti-oxidant activities of extracts from 21 plants. BMC Complement Altern Med. 2009;9:27.
[63] Wittenauer J, Mäckle S, Sußmann D, Schweiggert-Weisz U, Carle R. Inhibitory effects of polyphenols from grape pomace extract on collagenase and elastase activity. Fitoterapia. 2015;101:179-187.
[64] Chang TS. An updated review of tyrosinase inhibitors. Int J Mol Sci. 2009;10(6):2440-2475.
[65] Molgora B, Bateman R, Sweeney G, et al. Functional assessment of pharmacological telomerase activators in human T cells. Cells. 2013;2(1):57-66.
[66] Bernardes de Jesus B, Blasco MA. Telomerase at the intersection of cancer and aging. Trends Genet. 2013;29(9):513-520.
[67] Shay JW. Role of telomeres and telomerase in aging and cancer. Cancer Discov. 2016;6(6):584-593.
[68] Nicolson GL. Mitochondrial dysfunction and chronic disease: treatment with natural supplements. Integr Med (Encinitas). 2014;13(4):35-43.
[69] Scarpulla RC. Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network. Biochim Biophys Acta. 2011;1813(7):1269-1278.
[70] Picard M, Wallace DC, Burelle Y. The rise of mitochondria in medicine. Mitochondrion. 2016;30:105-116.
[71] Mattson MP. Hormesis defined. Ageing Res Rev. 2008;7(1):1-7.
[72] Calabrese V, Cornelius C, Dinkova-Kostova AT, et al. Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity. Biochim Biophys Acta. 2012;1822(5):753-783.
[73] Calabrese EJ, Mattson MP. Hormesis provides a generalized quantitative estimate of biological plasticity. J Cell Commun Signal. 2011;5(1):25-38.
[74] Kirkland JL, Tchkonia T. Senolytic drugs: from discovery to translation. J Intern Med. 2020;288(5):518-536.
[75] Xu M, Pirtskhalava T, Farr JN, et al. Senolytics improve physical function and increase lifespan in old age. Nat Med. 2018;24(8):1246-1256.
[76] Bone K, Mills S. Principles and Practice of Phytotherapy: Modern Herbal Medicine. 2nd ed. Churchill Livingstone; 2013.
[77] Awang DVC. Tyler’s Herbs of Choice: The Therapeutic Use of Phytomedicinals. 3rd ed. CRC Press; 2009.
[78] Chandrasekhar K, Kapoor J, Anishetty S. A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian J Psychol Med. 2012;34(3):255-262.
[79] Shergis JL, Zhang AL, Zhou W, Xue CC. Panax ginseng in randomised controlled trials: a systematic review. Phytother Res. 2013;27(7):949-965.
[80] Birks J, Evans JG. Ginkgo biloba for cognitive impairment and dementia. Cochrane Database Syst Rev. 2009;(1):CD003120.
[81] Hung SK, Perry R, Ernst E. The effectiveness and efficacy of Rhodiola rosea L.: a systematic review of randomized clinical trials. Phytomedicine. 2011;18(4):235-244.
[82] Hewlings SJ, Kalman DS. Curcumin: a review of its effects on human health. Foods. 2017;6(10):92.
[83] Mashhadi NS, Ghiasvand R, Askari G, Hariri M, Darvishi L, Mofid MR. Anti-oxidative and anti-inflammatory effects of ginger in health and physical activity: review of current evidence. Int J Prev Med. 2013;4(Suppl 1):S36-S42.
[84] Panossian A, Wikman G. Evidence-based efficacy of adaptogens in fatigue, and molecular mechanisms related to their stress-protective activity. Curr Clin Pharmacol. 2009;4(3):198-219.
[85] Aguiar S, Borowski T. Neuropharmacological review of the nootropic herb Bacopa monnieri. Rejuvenation Res. 2013;16(4):313-326.
[86] Peterson CT, Denniston K, Chopra D. Therapeutic uses of Triphala in Ayurvedic medicine. J Altern Complement Med. 2017;23(8):607-614.
[87] Sharma R, Martins N, Kuca K, et al. Chyawanprash: a traditional Indian bioactive health supplement. Biomolecules. 2019;9(5):161.
[88] Panossian A, Wikman G. Effects of adaptogens on the central nervous system and the molecular mechanisms associated with their stress-protective activity. Pharmaceuticals (Basel). 2010;3(1):188-224.
[89] Vaughn AR, Branum A, Sivamani RK. Effects of turmeric (Curcuma longa) on skin health: a systematic review of the clinical evidence. Phytother Res. 2016;30(8):1243-1264.
[90] Bylka W, Znajdek-Awiżeń P, Studzińska-Sroka E, Brzezińska M. Centella asiatica in cosmetology. Postepy Dermatol Alergol. 2013;30(1):46-49.
[91] Dhaliwal S, Rybak I, Ellis SR, et al. Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing. Br J Dermatol. 2019;180(2):289-296.
[92] Peterson CT, Denniston K, Chopra D. Therapeutic uses of Triphala in Ayurvedic medicine. J Altern Complement Med. 2017;23(8):607-614.
[93] Choi J, Kim TH, Choi TY, Lee MS. Ginseng for health care: a systematic review of randomized controlled trials in Korean literature. PLoS One. 2013;8(4):e59978.
[94] Gediya SK, Mistry RB, Patel UK, Blessy M, Jain HN. Herbal plants: used as a cosmetics. J Nat Prod Plant Resour. 2011;1(1):24-32.
[95] Sahoo N, Manchikanti P, Dey S. Herbal drugs: standards and regulation. Fitoterapia. 2010;81(6):462-471.
[96] Fugh-Berman A. Herb-drug interactions. Lancet. 2000;355(9198):134-138.
[97] Panossian A, Wikman G. Evidence-based efficacy of adaptogens in fatigue, and molecular mechanisms related to their stress-protective activity. Curr Clin Pharmacol. 2009;4(3):198-219.
[98] Gurley BJ, Gardner SF, Hubbard MA, et al. In vivo effects of goldenseal, kava kava, black cohosh, and valerian on human cytochrome P450 1A2, 2D6, 2E1, and 3A4/5 phenotypes. Clin Pharmacol Ther. 2005;77(5):415-426.
[99] Dugoua JJ, Mills E, Perri D, Koren G. Safety and efficacy of ginkgo (Ginkgo biloba) during pregnancy and lactation. Can J Clin Pharmacol. 2006;13(3):e277-e284.
[100] Ang-Lee MK, Moss J, Yuan CS. Herbal medicines and perioperative care. JAMA. 2001;286(2):208-216.
[101] Berman JD, Straus SE. Implementing a research agenda for complementary and alternative medicine. Annu Rev Med. 2004;55:239-254.
[102] Posadzki P, Watson L, Ernst E. Herb-drug interactions: an overview of systematic reviews. Br J Clin Pharmacol. 2013;75(3):603-618.
[103] Izzo AA, Ernst E. Interactions between herbal medicines and prescribed drugs: an updated systematic review. Drugs. 2009;69(13):1777-1798.
[104] Izzo AA, Ernst E. Interactions between herbal medicines and prescribed drugs: an updated systematic review. Drugs. 2009;69(13):1777-1798.
[105] Yeh GY, Eisenberg DM, Kaptchuk TJ, Phillips RS. Systematic review of herbs and dietary supplements for glycemic control in diabetes. Diabetes Care. 2003;26(4):1277-1294.
[106] Berman JD, Straus SE. Implementing a research agenda for complementary and alternative medicine. Annu Rev Med. 2004;55:239-254.
[107] Patisaul HB, Jefferson W. The pros and cons of phytoestrogens. Front Neuroendocrinol. 2010;31(4):400-419.
[108] Qaragholi H, Garousi N, Vahed SZ, Montazersaheb S, Hejazi MS. Herbal compounds for skin rejuvenation: a review. Biomed Pharmacother. 2022;150:113008.
[109] Khonthun C, Sittithumcharee G, Takahashi H, Yano T, Ishikawa T, Lirdprapamongkol K. Herbal medicine for healthy aging: pharmacological basis and strategies of multicomponent herbal formula against aging-related multimorbidity. Biomolecules. 2023;13(2):350.
[110] Lim HS, Kim OS, Kim BY, Jeong SJ. Apiaceae plants as a promising source for type 2 diabetes management: review of preclinical and clinical evidence. Nutrients. 2020;12(5):1326.
[111] Qaragholi H, Garousi N, Vahed SZ, Montazersaheb S, Hejazi MS. Herbal compounds for skin rejuvenation: a review. Biomed Pharmacother. 2022;150:113008.
[112] Hussin M, Hamid AA, Mohamad S, Saari N, Ismail M, Bejo MH. Protective effect of Centella asiatica extract and powder on oxidative stress in rats. Food Chem. 2007;100(2):535-541.
[113] Ratz-Łyko A, Arct J, Pytkowska K. Moisturizing and antiinflammatory properties of cosmetic formulations containing Centella asiatica extract. Indian J Pharm Sci. 2016;78(1):27-33.
[114] Bonifácio BV, Silva PB, Ramos MA, Negri KM, Bauab TM, Chorilli M. Nanotechnology-based drug delivery systems and herbal medicines: a review. Int J Nanomedicine. 2014;9:1-15.
[115] Lim HS, Kim OS, Kim BY, Jeong SJ. Apiaceae plants as a promising source for type 2 diabetes management: review of preclinical and clinical evidence. Nutrients. 2020;12(5):1326.
[116] Khonthun C, Sittithumcharee G, Takahashi H, Yano T, Ishikawa T, Lirdprapamongkol K. Herbal medicine for healthy aging: pharmacological basis and strategies of multicomponent herbal formula against aging-related multimorbidity. Biomolecules. 2023;13(2):350.
[117] Kirkland JL, Tchkonia T. Senolytic drugs: from discovery to translation. J Intern Med. 2020;288(5):518-536.
[118] Raina K, Kumar S, Dhar D, Agarwal R. Silibinin and colorectal cancer chemoprevention: a comprehensive review of preclinical and clinical evidence. Phytother Res. 2016;30(10):1633-1644.
[119] Westfall S, Lomis N, Prakash S. Longevity extension in Drosophila through gut-brain communication. Sci Rep. 2018;8(1):8362.
[120] Khonthun C, Sittithumcharee G, Takahashi H, Yano T, Ishikawa T, Lirdprapamongkol K. Herbal medicine for healthy aging: pharmacological basis and strategies of multicomponent herbal formula against aging-related multimorbidity. Biomolecules. 2023;13(2):350.
[121] Kiefte-de Jong JC, Mathers JC, Franco OH. Nutrition and healthy ageing: the key ingredients. Proc Nutr Soc. 2014;73(2):249-259.
[122] Garatachea N, Pareja-Galeano H, Sanchis-Gomar F, et al. Exercise attenuates the major hallmarks of aging. Rejuvenation Res. 2015;18(1):57-89.
[123] Mander BA, Winer JR, Walker MP. Sleep and human aging. Neuron. 2017;94(1):19-36.
[124] Epel ES, Lithgow GJ. Stress biology and aging mechanisms: toward understanding the deep connection between adaptation to stress and longevity. J Gerontol A Biol Sci Med Sci. 2014;69(Suppl 1):S10-S16.
[125] Holt-Lunstad J, Smith TB, Layton JB. Social relationships and mortality risk: a meta-analytic review. PLoS Med. 2010;7(7):e1000316.
